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- Response: Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults (Diabetes Metab J 2011;35:551-7)
- Hyung Geun Oh, Eun-Jung Rhee, Tae-Woong Kim, Kyung Bok Lee, Jeong-Ho Park, Kwang-Ik Yang, Dushin Jeong, Hyung-Kook Park
- Diabetes Metab J. 2012;36(1):81-82. Published online February 17, 2012
- DOI: https://doi.org/10.4093/dmj.2012.36.1.81
- 3,255 View
- 31 Download
- Higher Glycated Hemoglobin Level Is Associated with Increased Risk for Ischemic Stroke in Non-Diabetic Korean Male Adults
- Hyung Geun Oh, Eun-Jung Rhee, Tae-Woong Kim, Kyung Bok Lee, Jeong-Ho Park, Kwang-Ik Yang, Dushin Jeong, Hyung-Kook Park
- Diabetes Metab J. 2011;35(5):551-557. Published online October 31, 2011
- DOI: https://doi.org/10.4093/dmj.2011.35.5.551
- 4,196 View
- 57 Download
- 14 Crossref
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Abstract
PDF
PubReader Background The role of glycated hemoglobin (HbA1c) in the prediction of ischemic stroke in non-diabetic subjects is not clear. We performed a study to analyze the role of HbA1c in the risk prediction of ischemic stroke in non-diabetic Korean males adult.
Methods A total of 307 non-diabetic male patients with ischemic stroke were enrolled, and 253 age-matched control subjects without a history of diabetes, hypertension, or cardiovascular disease were selected from a Health Check-up database. Anthropometric measurement data, fasting glucose level, lipid profile, and HbA1c level were available for all subjects. Associations of the variables and the presence or absence of ischemic stroke were analyzed.
Results The ischemic stroke patient group had significantly higher HbA1c levels (5.8±0.5% vs. 5.5±0.5%,
P <0.01) and mean systolic and diastolic blood pressure compared with the control group. Among the variables, smoking, low high density lipoprotein cholesterol, systolic blood pressure, and HbA1c were the significant determinants for ischemic stroke. The highest quartile of HbA1c showed a 9.6-fold increased odds ratio for ischemic stroke compared with the lowest quartile of HbA1c (odds ratio, 9.596; 95% confidence interval, 3.859 to 23.863,P <0.01). The proportion of ischemic stroke patients showed a significant trend for increment as the deciles of HbA1c increased (P for trend <0.01).Conclusion Higher HbA1c indicated a significantly increased risk for ischemic stroke after adjusting for other confounding variables in non-diabetic Korean adult males. HbA1c might have significance in predicting the risk for ischemic stroke even in the non-diabetic range.
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Citations
Citations to this article as recorded by
- Association of Glycated Hemoglobin With Acute Ischemic Stroke in a Tertiary Care Center in a Tribal Region of Jharkhand
Shimpy Priya, Vikas Mardi, Siddharth Kapoor, Abhay Kumar, Usha Saroj, Ajit Dungdung, Raunak Rishu
Cureus.2024;[Epub] CrossRef - Machine learning algorithms identify demographics, dietary features, and blood biomarkers associated with stroke records
Jundong Liu, Elizabeth L. Chou, Kui Kai Lau, Peter Y.M. Woo, Jun Li, Kei Hang Katie Chan
Journal of the Neurological Sciences.2022; 440: 120335. CrossRef - HbA1c and clinical outcomes after endovascular treatment in patients with posterior circulation large vessel occlusion: a subgroup analysis of a nationwide registry (BASILAR)
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Therapeutic Advances in Neurological Disorders.2020; 13: 175628642098135. CrossRef - Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: the ESCARVAL-risk study
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Rong-Ren Kuang, Fang-Zhou Liu, Yun-Peng Li, Wei-Dong Lin, Hua-Sheng Liang, Ai-Hua Chen
European Journal of Medical Research.2017;[Epub] CrossRef - Early New Ischemic Lesions Located Outside the Initially Affected Vascular Territory Appear More Often in Stroke Patients with Elevated Glycated Hemoglobin (HbA1c)
Tim Bastian Braemswig, Christian H. Nolte, Jochen B. Fiebach, Tatiana Usnich
Frontiers in Neurology.2017;[Epub] CrossRef - Blood Pressure Is the Determinant for the Increased Risk for Intracranial Arterial Stenosis in Subjects with Elevated Glycated Hemoglobin Levels: The Kangbuk Samsung Health Study
Hyung-Geun Oh, Eun-Jung Rhee
Journal of Stroke and Cerebrovascular Diseases.2016; 25(11): 2729. CrossRef - Prognosis of Ischemic Stroke With Newly Diagnosed Diabetes Mellitus According to Hemoglobin A1c Criteria in Chinese Population
Jing Jing, Yuesong Pan, Xingquan Zhao, Huaguang Zheng, Qian Jia, Hao Li, Ling Guan, Liping Liu, Chunxue Wang, Xia Meng, Yan He, Yilong Wang, Yongjun Wang
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Yun-Yu Chen, Yenn-Jiang Lin, Eric Chong, Pei-Chun Chen, Taz-Fan Chao, Shih-Ann Chen, Kuo-Liong Chien, An Pan
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Elizabeth Guerrero-Berroa, Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Andrew Levy, Derek Leroith, Michal S. Beeri
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Diabetes & Metabolism Journal.2014; 38(1): 58. CrossRef - Glycated Hemoglobin and All-Cause and Cause-Specific Mortality in Singaporean Chinese Without Diagnosed Diabetes: The Singapore Chinese Health Study
Michael P. Bancks, Andrew O. Odegaard, James S. Pankow, Woon-Puay Koh, Jian-Min Yuan, Myron D. Gross, Mark A. Pereira
Diabetes Care.2014; 37(12): 3180. CrossRef - Letter: Higher Glycated Hemoglobin Level Is Associated with Increased Risk of Ischemic Stroke in Non-Diabetic Korean Male Adults (Diabetes Metab J 2011;35:551-7)
Seok Hong Lee, Jihyun Ahn, Jaetaek Kim
Diabetes & Metabolism Journal.2012; 36(1): 79. CrossRef
- Association of Glycated Hemoglobin With Acute Ischemic Stroke in a Tertiary Care Center in a Tribal Region of Jharkhand
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